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These hypotheses have sprung from its perceived potential to stimulate the production of collagen, elastin, and glycosaminoglycans, crucial intercellular matrix components

However, in some other tissues, IGF-I expression appears to be regulated by tissue specific trophic factors, as for example in uterus, where estrogens (and not GH) stimulate IGF-I expression[26], while follicle stimulating hormone is a major IGF-I regulator in ovary[27]

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