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The copper chaperone ATOX1 is a particularly compelling target in this context

10.1016/j.actbio.2019.04.011 99 GuoS.MengX.-w.YangX.-s.LiuX.-f.Ou-YangC.-h.LiuC

Evidence from clinical studies suggests that VE, either alone or in combination with other compounds, can significantly reduce pro-inflammatory cytokines such as IL-6, TGF-1, and MCP-1, while enhancing anti-inflammatory mediators including IL-10 and adiponectin