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Although curcumin holds promise as an anti-cancer agent, its practical application is hindered by its limited water solubility and stability in vitro environments as well as its low bioavailability in vivo studies [270,271,272]

Zhang, Y, Chen, F, Fonseca, NA, He, Y, Fujita, M, Nakagawa, H, Zhang, Z, Brazma, A, Amin, SB, Awadalla, P, Bailey, PJ, Brazma, A, Brooks, AN, Calabrese, C, Chateigner, A, Corts-Ciriano, I, Akdemir, KC, Chen, K, Akbani, R, Aldape, KD, Broaddus, R, Borresen-Dale, A, Cao, S, Chakravarty, D, Chen, Y, Czerniak, BA, Eils, R, El-Naggar, AK, Fan, Y, Gershenwald, JE, Han, L, Huse, J, von Kalle, C, Krishnamurthy, S, Lazar, A, Li, J, Liang, H, Lichter, P, Lu, Y, Mills, GB, Plass, C, Sood, AK, Su, X, Thompson, A, Van Loo, P, Wang, L , Wang, W, Weinstein, JN, Yuan, Y, Zhu, H

Chain-breaking antioxidants such as vitamins E and C halt the process of radical formation by stabilizing free radical molecules so that the chain-like process of radical formation is arrested

Kim, M.-K