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This modification can regulate gene expression by altering the interaction between the DNA and the proteins that bind to it 12,13

Repeating the experiment in these conditions resulted in an improvement in mice survival [108]

J Clin Endocrinol Metab 101:17541761 Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr (2012) Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: the National Health and Nutrition Examination Survey, 19992006