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Note that while elevated homocysteine is associated with an increased risk of Alzheimer's disease, systematic reviews of clinical trials comparing vitamin B12 supplementation to placebo groups have not shown a significant effect in preventing or slowing Alzheimer's disease or cognitive decline

(2) Fiona OLeary and Samir Samman (2010) Vitamin B12 in Health and Disease Nutrients, 2010 Mar 5, Volume 2 (Issue 3), Pages 299316

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