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We observed that a ferroptosis-like mechanism, induced by xCT inhibition with Erastin, at a non-lethal level, promoted features of ECs activation, such as proliferation, migration and vessel-like structures formation, concomitantly with the depletion of reduced glutathione (GSH) and increased levels of oxidative stress and lipid peroxides

GPx is a frontline defense against membrane lipid peroxidation and is central to how cells manage the constant low-level flux of hydrogen peroxide generated by normal metabolism

Western blot analysis indicated an increase in the expression levels of p53, cleaved caspase 9, cleaved caspase-3, cleaved PARP, and Bim, Bak, and Bad proteins [90]

found that ipamorelin accelerated gastric emptying in adult male rats [4]