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Human biological samples and associated data were provided by the Westdeutsche Biobank Essen (WBE, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

It is thought that over time, the disease shifts from an early hypermetabolic state to a hypometabolic state with decreased metabolites (251) and reduced energy production (185)

Because RP is a chronic condition, the development of a minimally invasive therapeutic that reduces frequency of application with local administration is appealing to reduce risk of non-adherence

doi: 10.1007/s00253-005-0212-6 486 ZhouZ.DangY.ZhouM.LiL.YuC.-H.FuJ.et al