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tabacum plants with reduced expression of GR were shown to display enhanced sensitivity to oxidative stress (Ding et al., AsA-GSH pathway in chloroplasts The AsA-GSH cycle plays a critical role in maintaining ROS homeostasis in chloroplasts

Well established mechanisms include myocardial energy depletion due to impaired adenosine triphosphate (ATP) synthesis and mitochondrial uncoupling, and increased mitochondrial oxidative stress

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Moreover, dendritic spines that receive most excitatory synaptic inputs have been shown to contain no mitochondria (Kasthuri et al., 2015), despite being sites of intense energy utilization