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doi: 10.1515/bchm2.1975.356.2.1113 140 UtermannG.HeesM.SteinmetzA

We found that HCC cell-secreted factor(s) inhibit(s) SAMHD1 by downregulating its mRNA, leading to the aberrant accumulation of cytosolic dNTPs

On the other hand, other mediators may also be part of the pathophysiological mechanisms triggered by oxidative stress in this kind of NP, such as aquaporin-1