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Factors Underlying Differences Between Fibroblast Growth Factor 21 Analogs While LY2405319 (244), PF-05231023 (183), efruxifermin (246), BFKB8488A (301), and MK-3655 (303) were observed to ameliorate dyslipidemia, with strong reductions in triglycerides and increases in HDL-cholesterol, only efruxifermin and MK-3655 have so far demonstrated the potential to increase insulin sensitivity and to improve glycemic control

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