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This can be a problem for your organs, which are now not getting enough oxygen, leading to a whole host of concerning symptoms, which include: Anemia Fatigue and weakness Depression Irritability Yellowing skin Soreness of mouth and tongue Weight loss or decreased appetite Numbness of extremities Vision problems Other neurological and psychological symptoms may include fogginess, confusion, and a shift in personality and behavior

NAD also plays a key role in DNA repair, healthy gene expression, and cell signaling

A deficiency can also cause a condition called megaloblastic anemia which creates larger, immature, and abnormal red blood cells and leads to impaired DNA synthesis

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