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Animal studies have shown that SCD1 knockdown or inhibition of cholesterol uptake significantly increases the sensitivity of GC stem cells to ferroptosis inducers, further suppressing their proliferative capacity (83)

With $100 million, he established OS Fund, a VC fund solely focused on deep tech and scientist-entrepreneurs whom Johnson characterizes as rewriting the operating systems of life. In their work he sees world-changing promise to address climate change, advance human health, and tackle other urgent challenges facing mankind

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Recent methodological advancesincluding organotypic slice cultures, three-dimensional brain organoids and in vivo imaging approachesoffer scalable and physiologically relevant platforms that more faithfully capture astrocyte heterogeneity and functional consequences