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What to avoid: High-potency exfoliants and prescription-strength retinoids, like glycolic acid peels, products with salicylic acid, and Tretinoin, are not appropriate for the periocular zone unless specifically formulated for it

Their action is based on various mechanisms but always leads to the induction of senescent cell death, consequently reducing their total number in the tissue [98]

Achieving this objective will require more sophisticated genetic models, such as knock-in mice expressing NIK mutants that retain kinase activity but are uncoupled from IKK activation

This potential interaction has been suggested as a contributing factor in tissue regeneration models