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Patients should be cautioned to tell their doctors if theyre taking PPIs and only use the drugs when necessary. Related: Gene therapy method developed to target damaged kidney cells Discovery may lead to improved treatment for chronic kidney disease More than 15 million Americans suffering from heartburn, ulcers and acid reflux have prescriptions for PPIs, which bring relief by reducing gastric acid

These pathways are particularly significant for macromolecules and surface-modified particulate systems, where ligand attachment or mucoadhesive coatings may enhance epithelial interaction and promote uptake, thereby increasing the likelihood of transport via olfactory and trigeminal neuronal pathways (Dhuria et al., 2010, Pardeshi and Belgamwar, 2013)