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Elevated levels of oxidative stress markers have been consistently reported in ME/CFS, including malondialdehyde (MDA), isoprostanes, 8-OH-deoxyguanosine, 2,3 diphosphoglyceric acid, thiobutyric acid, and protein carbonyls

463,464 It reduces inflammation and improves symptoms primarily by suppressing the effects of TNF- and is typically used in patients who do not respond to or are intolerant to conventional treatments such as 5-aminosalicylic acid

Atherosclerosis commences with the subendothelial retention and aggregation of cholesterol-rich LDL, which is mediated by the interaction of Apos and extracellular matrix (ECM) components such as proteoglycans (PGs) 11,12,16

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