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If its use is required, a reduced continuous infusion rate should be advised for infants with GA under 32 weeks, as their immature metabolic pathways slow drug clearance and place them at higher risk of accumulating excessive plasma concentrations during prolonged sedation or analgesic therapy (272)

In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26

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Tuxhorn JA, McAlhany SJ, Dang TD, Ayala GE, Rowley DR