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Most users tolerate this range without gastrointestinal upset, though doses above 5 grams may cause loose stools

The 2011 American Heart Association guidelines on triglyceride management recommended the use of marine-derived omega-3 fatty acid supplements (2-4 g/day of EPA plus DHA) under medical supervision to reduce triglyceride concentrations below 100 mg/dL (143)

Dietary adjustments often provide significant relief, including eating smaller, more frequent meals rather than large portions, avoiding high-fat or spicy foods that may exacerbate symptoms, and eating slowly to allow for better digestion