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Commentary siRNAs are double-stranded RNA molecules that suppress expression of the target genes through incorporation into the RNA-induced silencing complex, which mediates degradation of the targeted mRNA (Shen and Corey Citation2018, Sutton et al

In this model, the modest anti-fibrotic effects of semaglutide are not accompanied by improved hallmarks of NASH, suggesting complex hepatoprotective effects of semaglutide