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In mitochondria, LA is a vital cofactor for several enzymes (the oxoglutarate dehydrogenase complex [OGDC], pyruvate dehydrogenase complex [PDHC], branched-chain -ketoacid dehydrogenase complex [BCKDC]) that contribute to aerobic metabolism and nucleic acid synthesis [32, 33]

While niacinamide is generally considered neutral with respect to insulin sensitivity, high doses can increase hepatic glucose production and free fatty acid levels

Your answer to this fundamental question will heavily influence your choice between 5-Amino-1MQ vs AOD-9604

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