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Lifespan effects of ferroptosis inhibition or blocking iron accumulation Since Fe 2+ accumulates with ageing and contributes to C

Pitzschke A, Djamei A, Bitton F, Hirt H

A reduction in the mRNA level of inflammatory mediators (iNOS, IL-6, IFN-, and TNF-) and increased expression of HSP 70 and 90 and antioxidant proteins such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi were observed (Park et al., 2020)