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On the other hand, p-MET (especially pY1003) staining coincided with p-FAK and p-AKT expression, suggesting the role of c-MET activation in cell migration, invasion, and survival

This is the pharmacological basis for CagriSema : in REDEFINE 1, the combination produced 20.4% mean weight loss versus 11.8% for cagrilintide alone and 14.9% for semaglutide alone