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If you are not deficient in vitamin B12, then supplementation is unlikely to directly affect joint pain

Flavanols are natural compounds found in foods like cocoa, berries, apples, and grapes

The meta-analysis conducted in 2012 was found that GSTM1 null genotype, GSTM1 and GSTT1 double null genotype or GSTT1 null genotype and rs1695 polymorphism within the GSTP1 gene can correlate with an increased risk of cancer development [45]

Methylation happens when nutrients such as Folic Acid, Vitamin B6 and Vitamin B12 donate a methyl group (a molecule combo of one carbon and three hydrogen), and transfer it to a protein, enzyme, hormone or right onto DNA