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Sep 2016;17(3):443-448

First, avoid taking it while drinking alcohol, as alcohol can reduce its effectiveness and further stress your liver

Studies using human aortic endothelial cells (HAECs), human vascular smooth muscle cells (HVSMCs) and mouse models have shown that TMAO treatment increases phosphorylation of p38, JNK and ERK1/2 [38, 132]