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A study showed that serum sTFR levels were significantly higher and serum iron levels were significantly lower in patients with RA compared to healthy controls

Total body depletion of iron (absolute or true iron deficiency) will eventually result in a microcytic hypochromic anemia and hypochromasia (decreased rim of hemoglobin resulting in increased central pallor) will be evident in red blood cells on blood smear examination (see image on the right and images below)

[60] measured total dissolved protein in shoots as a plant health indicator, finding that subtoxic gadolinium concentrations (1.57 and 7.86 mg/L) increased protein levels, while a toxic concentration (31.5 mg/L) led to a significant 24.2% decrease

Symptoms typically begin with an insidious onset, evolving to a full syndrome over days to weeks