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doi: 10.1016/j.matbio.2023.02.004 36 KaipioKChenPRoeringPHuhtinenKMikkonenPOstlingPet al

Therefore, it could be hypothesized that until oxygen becomes limiting for FIH, NF-B regulates tumor cell growth and expansion through pyruvate-mediated competitive inhibition of PHD-2 (Figure 8)