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Based on the performance of models submitted to the original blind EuroSAMPL challenge, these results would place our approach among the more performing models, demonstrating strong generalization to unseen experimental data (Table 3)

Materials and Methods Animals This study was conducted with 12-week-old, 200 g body weight, male Albino Wistar rats, randomly assigned at six rats/group/interval

Unlike traditional antidepressants that target serotonin reuptake (SSRIs), PE-22-28 works downstream by modulating neuronal excitability directly

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