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This case is an instructive reminder for clinicians to take a detailed medical history, consider the likelihood of leptospirosis and anticipate JHR before initiating antibiotics, so that supportive care can be optimized as soon as possible

Adv Pharmacol 76 : 1337 This paper offers a masteful synthesis of how kynurenine pathway metabolties influence glutamatergic activity through direct effects on ionotropic and metabotropic glutamate receptors, vesicular glutamate transport and indirect effects at other recognition sites