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Transcriptomic analysis revealed that alkaline ceramidase 1 (ACER1), an enzyme that regulates the levels of ceramides, is a promising therapeutic target for inflammatory bowel diseases associated with SLC39A8

10.1021/np9800102 230 ShulmanL

Sabatier M, Birsen R, Lauture L, Mouche S, Angelino P, Dehairs J, et al

At the position of 5 and 75% of small intestinal length, a 20 cm intestinal segment was taken and opened longitudinally with a sharp scissor on an ice-cold surface to expose the epithelial surface