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Ferulic acid was shown to reduce weight gain and correct the HFD-induced gut microbiota imbalance, and significantly promoted the accumulation and receptor expression of short-chain fatty acid-producing bacteria in the intestine, including Olsenella, Eisenbergiella, Dubosiella, Clostridiales_unclassified , and Faecalibaculum , reduced endotoxigenic or obesity-associated bacteria, decreased LPS, and inhibited the colonic TLR4/NF-B pathway

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Thus, we suggest that one single application of the NO-synthase (NOS) blocker N(G)-nitro-L-arginine methyl ester (L-NAME) may induce retinal ischemia in rats, and that the stable pentadecapeptide BPC 157 may be the therapy, since it may interact with the NO-system and may counteract various adverse effects of L-NAME application (see Stupnisek et al., 2012,2015