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An intravenous formulation provides short-term replacement for the oral drug

In conclusion, ferroptosis shows hopeful potential in the treatment of CRPC, but further clinical studies are required to evaluate whether ferroptosis inducers in combination with ADT produce a survival benefit in CRPC patients compared with ADT alone and whether the genes associated with ferroptosis can achieve risk stratification of patients to select the targeted therapeutic modalities, or to guide the application of ferroptosis inducers based on predictors of ferroptosis that are sensitive to therapeutic modalities or not

Dose is 2-10 grams per day, in two divided doses

Mantovani G, Maccio A, Madeddu C, Mura L, Massa E, Mudu MC, Mulas C, Lusso MR, Gramignano G, Piras MB