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A pilot RCT of 89 patients undergoing laparoscopic radical prostatectomy found that, compared to normal saline, an intravenous bolus of 1 g/kg DEX at the start of surgery lowered the incidence of AKI and serum level of renal biomarkers like BUN, creatinine, and cystatin C

Both, GH and IGF-1 lead to a positive calcium balance via their effects on vitamin D metabolism, which is especially important in children due to the demands of their growing skeleton, whereas their effects on PTH are unclear