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A "MHC Class I molecule" as used everywhere herein is defined as a molecule which comprises 1 -3 subunits, including a heavy chain, a heavy chain combined with a light chain (beta 2 m), a heavy chain combined with a light chain (beta 2 m) through a flexible linker, a heavy chain combined with a peptide, a heavy chain combined with a peptide through a flexible linker, a heavy chain/beta 2 m dimer combined with a peptide, and a heavy chain/beta 2 m dimer with a peptide through a flexible linker to the heavy or light chain

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reported that mice with silenced MT1/2 genes developed severe HF, cardiac fibrosis, and oxidative stress, with these symptoms exacerbated by intermittent hypoxia

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