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To manage the risk of elevated transaminase levels, assess ALT and AST: within one month prior to initiation of XENPOZYME, within 72 hours prior to any infusion during dose escalation, which includes the first 3 mg/kg dose, or prior to the next scheduled XENPOZYME infusion upon resuming treatment following a missed dose

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The first steps of sterol biosynthesis occur in the cytosol and endoplasmic reticulum, where acetyl-CoA is converted to mevalonate by three enzymes: acetoacetyl-CoA thiolase, HMG-CoA synthase, and HMG-CoA reductase