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intranasal doses of approximately 120 mcg/kg used in animal research Timing: Evening administration, typically 30 to 60 minutes before intended sleep Onset: Sleep pressure reported within approximately 130 minutes of administration in human studies Duration: Effects on sleep architecture observed with both single doses and multi-day protocols Regarding cycling, the evidence is mixed

Nature 460 , 839847 (2009)

Silencing IGF-1R signaling has emerged as a promising strategy against cancer and for overcoming cancer drug resistance, as illustrated by a recent report of the antioxidant molecule vitamin D regulating apoptosis and autophagy and supporting the DNA repair process of cancer cells partly by silencing IGF-1R signaling and its downstream target, -catenin (14)

Minkler et al., 2021