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Acknowledgements Research in the laboratory of the authors has been supported, in part, by the Collaborative Accelerator for Transformative Research Endeavors grant, jointly awarded by The University of Texas at Austin and The University of Texas MD Anderson Cancer Center, the N.G

Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation

You can read more about how gut dysfunction fuels chronic symptoms in our SIBO and brain fog blog