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Following absorption in the distal ileum via receptors, it leaves the enterocytes to enter the portal blood, where it binds to the transport protein transcobalamin II and is carried to the bone marrow and other tissues

Safety Considerations and Provider-Guided Decision Making B12 is water-soluble and has no established upper intake limit

2.2 Recognizing B12 Deficiency Suboptimal B12 may present subtly: Neurological : Paresthesias in hands or feet, gait instability, cognitive fogginess. Psychiatric : Mood swings, irritability, depression

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