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Figure 2 2.1 The primary factor contributing to the deterioration in oocyte quality is the elevation in oxidative stress In women of advanced reproductive age, oocytes demonstrate elevated levels of reactive ROS as a consequence of mitochondrial dysfunction

Indeed, the clinical literature exhibits heterogeneity in design, dosing, duration, and outcome measures, frequent reliance on parent reported scales without uniform blinding, and underpowered samples that hinder strong inference and guideline development (Doherty et al., 2022

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Old collagen breaks down before new collagen fully matures