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Description

This mechanistic insight is strongly supported by in vivo evidence showing that anti-OPN antibodies, which mimic the effect of blocking thrombin-cleaved OPN, replicate a tumor suppression phenotype in knock-in mice engineered with a thrombin cleavage-resistant form of the protein [271]

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Nat Commun 15 , 1733 (2024)

Chronic pharmacological potentiation of this pathway could theoretically promote tumor development or progression in individuals with pre-existing pre-malignant cells