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TAP-VK1 ( 2a ) has various advantages in addition to the compact molecular size as follows: (i) high thiol specificity, (ii) convenient reaction condition for labeling, (iii) high labeling yield in both organic solvents and water, (iv) significant increase in fluorescence intensity after labeling so that background fluorescence of unreacted 2a do not disturb fluorescence observation, while the commonly used compact labeling reagents disturbed, and (v) direct treatment of the labeling reaction mixture is possible

Yang F, Luo N, Ren L, Ding W, Wu X (2025) Smart biodegradable hydrogels incorporating a photoactive Ir(III) complex for NIR-triggered oral cancer treatment

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Vallery-Radot, P