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Magnetic resonance imaging and pathology studies have revealed that the greater neurological progression seen in males correlates with chronic immune activation and increased iron accumulation at the rims of chronic white matter lesions as well as more intensive whole brain and grey matter atrophy and axon loss

Cancer 122 , 422 (2019)

The different systemic therapy techniques for managing breast cancer involve hormone therapy, chemotherapy, targeted therapy, and immunotherapy, all of which have a different mechanism for treatment and a different outcome, reliant on various factors (tumor grade, receptor status, and molecular subtype)

Two shots together also means a bigger cortisone dose, which can cause side effects such as tiredness in older patients