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EP300 usually regulates transcription factors mainly through acetylation and further activates cell cycle-related genes, thus affecting the progression of cancers 39

Exosomal miR-181d-5p derived from rapamycin-conditioned MDSC alleviated allograft rejection by targeting KLF6

While these agents effectively dampen excessive inflammation and improve symptoms, they also compromise systemic immune competence, leading to increased susceptibility to infections, malignancies, and long-term treatment-associated complications [249]

Balanced GABA activity is important for emotional regulation and preventing symptoms like anxiety and agitation