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doi: 10.1016/j.biopha.2015.02.029 333 NakahiraKHaspelJARathinamVALeeSJDolinayTLamHCet al

Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones

Single cell transcriptomic analyses indicate that capsaicin primarily activates TRPV1 expressing sensory nerve terminals within adipose tissue, indirectly modulating adipocyte metabolism through neuroendocrine or paracrine mechanisms rather than direct adipocyte engagement (69)