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Its effects are not just limited to one area and may also involve the brain and nerves, helping the body respond better to stress and injury

Consequently, the standardized mean difference (SMD) was selected as the effect size indicator

These G protein-coupled receptors (Waldhoer et al., 2004) undergo conformational changes upon heroin binding, thereby inhibiting adenylate cyclase activity, reducing cAMP production (Tedford and Zamponi, 2006), and subsequently impairing neuronal signaling (Figure 3)

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