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However, the American Medical Association has advised that a number of products being advertised as nootropic supplements have not been examined in terms of safety and efficacy

Three-dimensional response surface plots were likewise generated from the fitted models to visualize quadratic effects and two-factor interactions between input variables, with all remaining variables fixed at their midpoint levels, following standard response surface methodology practices 103

Besides, goiter may be experimentally induced in animals exposed to goitrogenic substances, like perchlorate or thiocyanates, which block iodine uptake in the thyroid gland, causing a similar compensatory rise in secretion of TSH and hyperplasia of thyroid cells (Nourani and Sadr 2023)

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