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13-15 Use of common migraine preventive therapies, such as topiramate, propranolol, and amitriptyline, for a duration of 8 weeks, reportedly reduced plasma glutamate levels as compared with levels in individuals with migraine before preventive treatment

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Grudzen C.R., Hwang U., Cohen J.A., Fischman M., Morrison R.S

We found that a unique subset of SKN-1 targets, the detoxification enzyme family of glutathione-s-transferases (GSTs), were among the most upregulated genes in our dataset, suggesting that changing AMDH-1 levels triggers a specific transcriptional output, likely driven by SKN-1