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The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity

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Circulation 131 , 771773 (2015)

Based on network pharmacology, molecular docking, and experimental validation, a mixture of Schisandra chinensis fruit improved kidney function and pathological changes in DKD rats, possibly by downregulating the AGEs/RAGE signaling pathway, further downregulating the expression of TNF-, IL-1, IL-6, upregulating IL-10, among other mechanisms (Li et al., 2023a)