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Preclinical research suggests NNMT inhibition may affect fat cell metabolism, insulin sensitivity, body weight, and energy expenditure in animal or cell models

Moreover, inhibition of the PI3K/Akt activation restrained the GHK-induced upregulation of miR-146a-3p and the downregulation of AQP4

Therefore, while aware that the pharmacological modulation of the NRF2/ARE pathway could undeniably offer new therapeutic opportunities for diseases related to OS, we should at the same time consider that most of the currently known activators of NRF2 are not particularly specific, leading to an increased risk of off target toxic effects