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Tombaugh and Sapolsky1993)

T cells are crucial components of the anti-tumor immune response, and multiple intrinsic T-cell features significantly influence the outcomes of CAR-T cell therapy

Proteins were separated by electrophoresis on 7.5%, 10% or 12% polyacrylamide gel (depending on the molecular weight of protein), and then electrophoretically transferred to a polyvinylidene difluoride (PVDF) membrane

Although kynurenine is a well-known immunosuppressive metabolite, its degradation by kynurenine-3-monooxygenase (KMO) and downstream enzymes produces quinolinic acid that shows potent antiviral effects