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Translational research on reserve against neurodegenerative disease: consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimers Association Reserve, Resilience and Protective Factors Professional Interest Area working groups

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Given the essential role of astrocytes in clearing and detoxifying many substances and the changes in astrocyte functions that such substances can evoke, it is interesting to consider (and worthy of more extensive investigation) that chronic exposure to trace amounts of such substances might act as risk factors and comorbidities in a variety of CNS neurodegenerative conditions

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