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In particular, H 2 S, considered highly toxic, a poisonous gas with a typical odor of rotten eggs, is now classified among the endogenously produced gasotransmitters involved in many cell homeostatic processes as nitric oxide (NO) and carbon monoxide (CO), each other interacting [44,45]

Role of ferroptosis in PDAC development The tumor suppressive role of ferroptosis Genetic alterations in PDAC often involve key oncogenes and classical cancer signaling pathways

This finding brought together the antioxidant property of UA with the consistently topical concept of oxidative stress as a critical factor in the pathogenesis of PD

Mutations in the HFE gene are the major cause of hereditary hemochromatosis, a genetic disorder characterized by impaired regulation of TfR-mediated iron uptake, leading to excessive iron absorption and iron overload in organs such as the liver, heart, pancreas, and joints, ultimately resulting in tissue damage (Brissot et al., 2018